Profile
| Keywords: | Computational Psychiatry, Brain Disorders, Machine Learning, Aging |
Trained in mathematics (BSc), psychology (MSc), computational neuroscience (PhD), neuroimaging and psychiatry (postdoc), I have a strong passion for understanding the fundamental mechanisms of how the brain works and how to cure the brain when the mechanisms are disturbed. Recently, our lab has focused on translational research of predicting and improving real-world outcomes of mental and substance use disorders and substance overdose using electronic health data and machine learning.
As the Canada Research Chair in Computational Psychiatry (Tier 2), I am always seeking young talents to work with as graduate students (Masters and PhD) and postdoctoral fellows who are passionate about mental disorders and use their analytical, clinical and communication expertise to help patients, clinicians, policymakers and stakeholders. See one of the positions available here: https://apps.ualberta.ca/careers/posting/949.
My main research interests are:
1) Computational Psychiatry and Precision Medicine in Mental Health. The aim is to develop translational tools that can provide accurate and personalized diagnosis and treatment optimization for mental and substance use disorders. This can be achieved by identifying objective markers associated with mental disorders and their treatment outcomes through multimodal data, including electronic health records, brain imaging, genetic, biological, behavioural, cognitive and clinical measurements, and by applying advanced machine learning and statistical algorithms to these data.
2) Aging. Using large-scale data and machine learning techniques, our lab is interested in how lifestyle, environmental, social, cognitive, and genetic factors affect how we age, especially with respect to the interaction between mental and physical health during aging.
More information about our lab: https://sites.google.com/ualberta.ca/computational-psychiatry-lab/ AI4Society Funded ProjectsOutputs
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| Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia University of Alberta | Publication | 2019-01-01 | X. Zhang, M. Yang, X. Du, W. Liao, D. Chen, F. Fan, M. Xiu, Q. Jia, Y. Ning, X. Huang, F. Wu, J.C. Soares, Bo Cao, L. Wang, H. Chen | | Predicting individual responses to the electroconvulsive therapy with hippocampal subfield volumes in major depression disorder University of Alberta | Publication | 2018-01-01 | Bo Cao, Q. Luo, Y. Fu, L. Du, T. Qiu, X. Yang, X. Chen, Q. Chen, J.C. Soares, R.Y. Cho, X.Y. Zhang, H. Qiu | | Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia University of Alberta | Publication | 2018-01-01 | X.-E. Lang, D. Zhu, G. Zhang, X. Du, Q. Jia, G. Yin, D. Chen, M. Xiu, Bo Cao, L. Wang, Xinming Li, J.C. Soares, X.Y. Zhang | | Hippocampal subfield volumes in children and adolescents with mood disorders University of Alberta | Publication | 2018-01-01 | J. Tannous, H. Amaral-Silva, Bo Cao, M.-J. Wu, G.B. Zunta-Soares, I. Kazimi, C. Zeni, B. Mwangi, J.C. Soares | | Hippocampal Subfield Volumes in Patients With First-Episode Psychosis University of Alberta | Publication | 2018-01-01 | V. Baglivo, Bo Cao, B. Mwangi, M. Bellani, C. Perlini, A. Lasalvia, N. Dusi, C. Bonetto, D. Cristofalo, F. Alessandrini, G. Zoccatelli, E. Ciceri, L. Dario, C. Enrico, P. Francesca, F. Mazzi, S. Paolo, M. Balestrieri, J.C. Soares, M. Ruggeri, P. Brambilla | | Association of Selective Serotonin Reuptake Inhibitors and Bone Mineral Density in Elderly Women University of Alberta | Publication | 2018-01-01 | S. Saraykar, V. John, Bo Cao, M. Hnatow, C.G. Ambrose, N. Rianon | | Cortical thickness patterns as state biomarker of anorexia nervosa University of Alberta | Publication | 2018-01-01 | L. Lavagnino, B. Mwangi, Bo Cao, M.E. Shott, J.C. Soares, G.K.W. Frank | | Obesity and frontal-striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative University of Alberta | Publication | 2018-01-01 | Rodrigo B Mansur, Roger S McIntyre, Bo Cao, Yena Lee, Japiassú | | MR Spectroscopy Findings of the Basal Ganglia in Bipolar Disorders: a Systematic Review University of Alberta | Publication | 2018-01-01 | H.E. Wu, T. Melicher, Bo Cao, M. Sanches, J.A. Stanley, G. Zunta-Soares, B. Mwangi, J.C. Soares | | Erratum to: Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study University of Alberta | Publication | 2017-09-01 | Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares, Jair C. Soares | | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders University of Alberta | Publication | 2017-01-01 | Bo Cao, B. Mwangi, I.C. Passos, M.-J. Wu, Z. Keser, G.B. Zunta-Soares, D. Xu, K.M. Hasan, J.C. Soares | | BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative University of Alberta | Publication | 2017-01-01 | RB Mansur, E Brietzke, RS McIntyre, Bo Cao, Y Lee, Japiassú | | Elevated Choline-Containing Compound Levels in Rapid Cycling Bipolar Disorder University of Alberta | Publication | 2017-01-01 | Bo Cao, J.A. Stanley, I.C. Passos, B. Mwangi, S. Selvaraj, G.B. Zunta-Soares, J.C. Soares | | Hippocampal subfield volumes in mood disorders University of Alberta | Publication | 2017-01-01 | Bo Cao, I.C. Passos, B. Mwangi, H. Amaral-Silva, J. Tannous, M.-J. Wu, G.B. Zunta-Soares, J.C. Soares | | The impact of machine learning techniques in the study of bipolar disorder: A systematic review University of Alberta | Publication | 2017-01-01 | Diego Librenza-Garcia, Bruno Jaskulski Kotzian, Jessica Yang, Benson Mwangi, Bo Cao, Luiza Nunes Pereira Lima, Mariane Bagatin Bermudez, Manuela Vianna Boeira, Flavio Kapczinski, Ives Cavalcante Passos | | Brain gyrification and neuroprogression in bipolar disorder University of Alberta | Publication | 2017-01-01 | Bo Cao, I.C. Passos, M.-J. Wu, G.B. Zunta-Soares, B. Mwangi, J.C. Soares | | Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group University of Alberta | Publication | 2017-01-01 | D. Librenza-Garcia, B.J. Kotzian, J. Yang, B. Mwangi, Bo Cao, L.N. Pereira Lima, M.B. Bermudez, M.V. Boeira, F. Kapczinski, I.C. Passos | | Bistable perception in normal aging: perceptual reversibility and its relation to cognition University of Alberta | Publication | 2018-01-01 | S. Saraykar, Bo Cao, L.S. Barroso, K.S. Pereira, L. Bertola, M. Nicolau, J.D. Ferreira, N.S. Dias, E.L. Vieira, A.L. Teixeira, A.P.M. Silva, B.S. Diniz | | Burnout and cognitive impairment: Associated with serum BDNF in a Chinese Han population University of Alberta | Publication | 2017-01-01 | S.C. He, Y.Y. Zhang, J.Y. Zhan, C. Wang, X.D. Du, G.Z. Yin, Bo Cao, Y.P. Ning, J.C. Soares, X.Y. Zhang | | Deep brain stimulation of the medial forebrain bundle: Distinctive responses in resistant depression University of Alberta | Publication | 2016-01-01 | A.J. Fenoy, P. Schulz, S. Selvaraj, C. Burrows, D. Spiker, Bo Cao, G. Zunta-Soares, P. Gajwani, J. Quevedo, J. Soares | | Inhibitory control in obesity and binge eating disorder: A systematic review and meta-analysis of neurocognitive and neuroimaging studies University of Alberta | Publication | 2016-01-01 | Luca Lavagnino, Danilo Arnone, Bo Cao, Jair C Soares, Sudhakar Selvaraj | | Reduced Inhibitory Control Mediates the Relationship Between Cortical Thickness in the Right Superior Frontal Gyrus and Body Mass Index University of Alberta | Publication | 2016-01-01 | L. Lavagnino, B. Mwangi, I.E. Bauer, Bo Cao, S. Selvaraj, A. Prossin, J.C. Soares | | Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele University of Alberta | Publication | 2016-01-01 | Bo Cao, I.E. Bauer, A.N. Sharma, B. Mwangi, T. Frazier, L. Lavagnino, G.B. Zunta-Soares, C. Walss-Bass, D.C. Glahn, F. Kapczinski, D.A. Nielsen, J.C. Soares | | Entorhinal Cortex Thickness across the Human Lifespan University of Alberta | Publication | 2016-01-01 | K.M. Hasan, B. Mwangi, Bo Cao, Z. Keser, N.J. Tustison, P. Kochunov, R.E. Frye, M. Savatic, J. Soares | | Identifying a clinical signature of suicidality among patients with mood disorders: A pilot study using a machine learning approach University of Alberta | Publication | 2016-01-01 | L. Lavagnino, D. Arnone, Bo Cao, J.C. Soares, S. Selvaraj | | Hippocampal volume and verbal memory performance in late-stage bipolar disorder University of Alberta | Publication | 2016-01-01 | Bo Cao, Ives Cavalcante Passos, Benson Mwangi, Isabelle E Bauer, Giovana B Zunta-Soares, Flá vio Kapczinski, Jair C Soares | | Individualized Prediction and Clinical Staging of Bipolar Disorders Using Neuroanatomical Biomarkers University of Alberta | Publication | 2016-01-01 | B. Mwangi, M.-J. Wu, Bo Cao, I.C. Passos, L. Lavagnino, Z. Keser, G.B. Zunta-Soares, K.M. Hasan, F. Kapczinski, J.C. Soares | | Interaction between BDNF rs6265 Met allele and low family cohesion is associated with smaller left hippocampal volume in pediatric bipolar disorder University of Alberta | Publication | 2016-01-01 | C.P. Zeni, B. Mwangi, Bo Cao, K.M. Hasan, C. Walss-Bass, G. Zunta-Soares, J.C. Soares | | Increased interleukin-2 serum levels were associated with psychopathological symptoms and cognitive deficits in treatment-resistant schizophrenia University of Alberta | Publication | 2015-01-01 | Y. Tan, Y. Li, S. Tan, Z. Wang, F.-D. Yang, Bo Cao, G.B. Zunta-Soares, J.C. Soares, X.Y. Zhang | | Tuning Properties of MT and MSTd and Divisive Interactions for Eye-Movement Compensation University of Alberta | Publication | 2015-01-01 | Bo Cao, E. Mingolla, A. Yazdanbakhsh | | Development and validation of a brain maturation index using longitudinal neuroanatomical scans University of Alberta | Publication | 2015-01-01 | Bo Cao, B. Mwangi, K.M. Hasan, S. Selvaraj, C.P. Zeni, G.B. Zunta-Soares, J.C. Soares | | Changes in the corpus callosum in women with late-stage bipolar disorder University of Alberta | Publication | 2015-01-01 | L. Lavagnino, Bo Cao, B. Mwangi, M.-J. Wu, M. Sanches, G.B. Zunta-Soares, F. Kapczinski, J. Soares | | Perceptual, cognitive, and personality rigidity in Parkinson\textquotesingle s disease University of Alberta | Publication | 2015-03-01 | Mirella Dí az-Santos, Bo Cao, Arash Yazdanbakhsh, Daniel J. Norton, Sandy Neargarder, Alice Cronin-Golomb | | A computational study of brightness-related responses in visual cortex University of Alberta | Publication | 2013-01-01 | Bo Cao, E. Mingolla, A. Yazdanbahksh | | CACNB 2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania University of Alberta | Publication | 2020-05-01 | Jianshan Chen, Jiuwei Tan, Andy Greenshaw, Jeff Sawalha, Yang Liu, Xiaofei Zhang, Wenjin Zou, Xiaofang Cheng, Wenhao Deng, Yizhi Zhang, Liqian Cui, Chuihong Liu, Jiaqi Sun, Xiongchao Cheng, Qiuxia Wu, Suyi Li, Siming Mai, Xiaofeng Lan, Yingmei Chen, Yinglian Cai, Chaodun Zheng, Daomeng Cheng, Bin Zhang, Chanjuan Yang, Xuan Li, Xinmin Li, Biyu Ye, Muhammad Yousefnezhad, Yamin Zhang, Liansheng Zhao, Jair C. Soares, Xiangyang Zhang, Tao Li, Bo Cao, Liping Cao | | Resting-state functional connectivity of the anterior cingulate cortex in young adults depressed patients with and without suicidal behavior University of Alberta | Publication | 2020-04-01 | Haitang Qiu, Bo Cao, Jun Cao, Xinke Li, Jianmei Chen, Wo Wang, Zhen Lv, Shuang Zhang, Weidong Fang, Ming Ai, Li Kuang | | Basal ganglia volumetric changes in psychotic spectrum disorders University of Alberta | Publication | 2019-01-01 | | | Plasma IL-17A levels in patients with late-life depression University of Alberta | Publication | 2018-01-01 | Sudhakar Selvaraj, Chris Walker, Danilo Arnone, Bo Cao, Paul Faulkner, Philip J Cowen, Jonathan P Roiser, Oliver Howes | | Social Media and the Transformation of Healthcare: A Viewpoint (Preprint) University of Alberta | Publication | 2020-10-01 | | | Variability may limit the translation of neuroimaging findings comment on \textquotedblleft Variability in the analysis of a single neuroimaging dataset by many teams\textquotedblright University of Alberta | Publication | 2020-12-01 | | | Virtual Trauma-Focused Therapy for Military Members, Veterans, and Public Safety Personnel with Post-Traumatic Stress Injury: A Systematic Scoping Review (Preprint) University of Alberta | Publication | 2020-07-01 | Chelsea Jones, Antonio Miguel-Cruz, Lorraine Smith-MacDonald, Emily Cruikshank, Delaram Baghooi, Avneet Kaur Chohan, Alexa Laidlaw, Allison White, Bo Cao, Vincent Agyapong, Lisa Burback, Olga Winkler, Phillip R. Sevigny, Liz Dennett, Martin Ferguson-Pell, Andy Greenshaw, Suzette Bré mault-Phillips | | Major challenges and limitations of big data analytics University of Alberta | Publication | 2019-01-01 | | | Treatment response prediction and individualized identification of first-episode drug-naï ve schizophrenia using brain functional connectivity University of Alberta | Publication | 2020-01-01 | Bo Cao, R.Y. Cho, D. Chen, M. Xiu, L. Wang, J.C. Soares, X.Y. Zhang | | Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study University of Alberta | Publication | 2018-01-01 | | | Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder University of Alberta | Publication | 2021-06-01 | Faramarz Jabbari-zadeh, Bo Cao, Jeffrey A. Stanley, Yang Liu, Mon-Ju Wu, Jonika Tannous, Mizuki Lopez, Marsal Sanches, Benson Mwangi, Giovana B. Zunta-Soares, Jair C. Soares | | Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study University of Alberta | Publication | 2018-01-01 | Bo Cao, Yang S. Liu, Alessandro Selvitella, Diego Librenza-Garcia, Ives Cavalcante Passos, Jeffrey Sawalha, Pedro Ballester, Jianshan Chen, Shimiao Dong, Fei Wang, Flavio Kapczinski, Serdar Dursun, Xin-Min Li, Russell Greiner, Andy Greenshaw | | Altered neurochemistry in the anterior white matter of bipolar children and adolescents: a multivoxel 1H MRS study University of Alberta | Publication | 2020-11-01 | Jonika Tannous, Bo Cao, Jeffrey A. Stanley, Giovana B. Zunta-Soares, Benson Mwangi, Marsal Sanches, Jair C. Soares | | Effectiveness of cognitive behavioral therapy in treating bipolar disorder: A n updated meta-analysis with randomized controlled trials University of Alberta | Publication | 2016-01-01 | Bi-Yu Ye, Ze-Yu Jiang, Xuan Li, Bo Cao, Li-Ping Cao, Yin Lin, Gui-Yun Xu, Guo-Dong Miao | | Individualized identification of euthymic bipolar disorder using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and machine learning University of Alberta | Publication | 2016-01-01 | Mon-Ju Wu, Ives Cavalcante Passos, Isabelle E Bauer, Luca Lavagnino, Bo Cao, Giovana B Zunta-Soares, Flá vio Kapczinski, Benson Mwangi, Jair C Soares | | Erratum to: Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study (International Journal of Bipolar Disorders, (2017), 5, 1, (32), 10.1186/s40345-017-0101-9) University of Alberta | Publication | 2017-01-01 | M.-J. Wu, B. Mwangi, I.C. Passos, I.E. Bauer, Bo Cao, T.W. Frazier, G.B. Zunta-Soares, J.C. Soares | | Evidence of altered membrane phospholipid metabolism in the anterior cingulate cortex and striatum of patients with bipolar disorder I: A multi-voxel 1H MRS study University of Alberta | Publication | 2016-01-01 | Bo Cao, J.A. Stanley, S. Selvaraj, B. Mwangi, I.C. Passos, G.B. Zunta-Soares, J.C. Soares | | The effect of contrast intensity and polarity in the achromatic watercolor effect University of Alberta | Publication | 2011-01-01 | Bo Cao, Arash Yazdanbakhsh, Ennio Mingolla | | Validating a cross-sectional brain development index with longitudinal brain images University of Alberta | Publication | 2018-01-01 | Bo Cao, Benson Mwangi, Khader M Hasan, Sudhakar Selvaraj, Giovana B Zunta-Soares, Jair C Soares |
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